Name of the Faculty: Dr. (Mrs.) Anuradha S. Majumdar

Designation: Associate Professor of Pharmacology

Email: anuradha.majumdar@gmail.com anuradha.majumdar@bcp.edu.in

Educational Qualifications:

Sr no.	Degree	University	Year of Passing
1)	Ph. D. (Tech) (Pharmacology)	University of Mumbai	2006
2)	M. Pharm (Pharmacology)	Nagpur University	1996
3)	B.Pharm	Nagpur University	1994

Awards and Fellowships:

Sr no.	Award/Fellowship	Year of Receipt
1)	Chaired a symposium at the Annual Conference of Indian Pharmacological Society IPSCON-2017 organized by Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s NMIMS, Mumbai from 15th to 17th February 2018	2018
2)	Sadarani B. N., Majumdar A. S., “Management of rheumatoid arthritis with transdermal nanogel formulation of methotrexate” Won the Silver medal at the western zone Anveshan research convention 18 held on 14-15th February 2018 at Ganpat University, Mehsana, Gujarat.	2018
3)	Speaker agreement of PhD student Ms. Prajakta Sangole with Boerhinger Ingelheim International, Germany with a travel grant limit of Euro 5000 to attend and present poster titled ‘Evaluating the potential of Dabigatran etexilate in treatment of metastatic colon cancer’ at the European Cancer Congress 2017 from 27-30 January 2017	2017
4)	Gold medal in Avishkar 2014 (Maharashtra state level), UG level in Jalgaon, Maharashtra for the paper “Quercetin rich extract from onion peel and its antioxidant activity”	2014
5)	Consolation prize in Avishkar 2012 (Maharashtra state level), University of Mumbai, Scientific Competition on the paper “Resveratrol: Potential to combat against corticosteroid insensitivity in COPD”	2012
6)	Paper entitled "Exacerbation of alcohol- induced oxidative stress in rats by polyunsaturated fatty acids and iron load" authored by ShilpaPatere, A. S. Majumdar and M.N. Saraf published in the Indian Journal of Pharmaceutical Sciences, 2011; 73 (2) 152-158, has been adjudged as the best paper in the field of Pharmacology & Clinical Pharmacy for Prof M. L. Khorana Memorial Prize of Indian Pharmaceutical Association for the year 2011	2011
7)	Member of the senate of the University of Mumbai	2010
8)	Received Shri Salebhai A. Vali Memorial gold medal for standing first in order of merit in M. Pharm in Nagpur University	1996

Recent Publications:

Sr no.	Paper Title	Journal / Year / Vol / Page
1)	Optimization and evaluation of mucoadhesive buccal films loaded with resveratrol	Journal of Drug Delivery Science and Technology 44 (2018) 278–288
2)	Rats exposed to 2.45 GHz of non-ionizing radiation exhibit behavioral changes with increased brain expression of apoptotic caspase 3	Pathophysiology 25 (2018) 19–30
3)	“Pterostilbene ameliorates intracerebroventricular Streptozotocin induced memory decline in rats”.	Cognitive Neurodynamics. February 2017, 7 (1): 35-49, DOI 10.1007/s11571-016-9413-1
4)	“Nanofiber based drug delivery systems for skin: A promising therapeutic approach”	Journal of Drug delivery science and Technology 2017, 41: 124-133
5)	Resveratrol and pterostilbene ameliorates the metabolic derangements associated with smokeless tobacco in estrogen deficient female rats	Journal of Functional Foods, 2015, 23: 261-277

Recent Patents:(ALL)

Sr no.	Patent Title	Patent Number
1)	“A Novel Pharmaceutical Composition of topical Methotrexate in chronic inflammatory condition”	251524 (Indian Patent)
2)	Confidential	201721018366 (IP)
3)	Confidential	201721017985 (IP)
4)	Confidential	201721023419 (IP)

Recent Presentations: (Best Five in last five years)

Sr no.	Presentation Title(Best Five in last five years)	Conference Details
1)	Pterostilbene attenuates smokeless tobacco induced cardiovascular aberrations in estrogen deficient female rats through fostering the genes of energy metabolism	AAPS Annual meeting and Exhibition, held at orange county convention center, Orlando, Florida, USA, 25th -29th October 2015.
2)	“Transdermal delivery of methotrexate in rheumatoid arthritis: Are we deep enough”.	In annual European Congress of Rheumatology 2017, published in Annals of the Rheumatic Diseases, June 2017, Volume 76, Supplement 2
3)	Impact of smokeless tobacco on mitochondrial biogenesis in estrogen deficient female rats: Benefit of stilbenes.	National Symposium on Current Scenario of Pharmacological Experimentation and Interpretations on 2-3rd September 2016 at K M Kundnani College of Pharmacy, Cuffe Parade, Mumbai.
4)	To Profile Side Effect of chemotherapeutic Agents in cancer patients”	12th International Congress of Ethnopharmacology”, Traditional medicine and globalization- The future of ancient systems of medicine, February 17-19, 2012, Kolkata
5)	“Lidocaine, rimonabant, WIN 55,212-2 and capsazepine attenuate massive lung inflammation induced by the intratracheal administration of cigarette smoke extract in rats”	South Asian Chapter of American College of Clinical Pharmacology, Fifth International Annual Conference, Clinical Pharmacology-Discovery, development and beyond, 27th and 28th August 2011, Mumbai

Collaborations: (in current year)

Sr no.	Title	Industry/institute
1)	Targeting deacetylases and Methyl transferases to improve outcomes after allogeneic bone marrow transplantation in chemo-conditioning based murine model of acute graft versus host disease	Clinical Pharmacology lab (KS-102),Advanced Centre for Treatment, Research & Education in cancer (ACTREC),TMC,Kharghar,Navi-Mumbai
2)	Targeting the life - threatening complications (HVOD.GVHD) associated with allogeneic Haematopoietic Stem Cell Transplantation (allo HSCT).	Clinical Pharmacology lab (KS-102),Advanced Centre for Treatment, Research & Education in cancer (ACTREC),TMC,Kharghar,Navi-Mumbai
3)	Radiotracer based bio-distribution studies of a novel nanocarrier based transdermal delivery system for rheumatoid arthritis.	Board of Radiation and Isotope Technology, Vashi, Navi-Mumbai
4)	ADR monitoring in cancer wards	Tata Memorial Hospital, Parel, Mumbai
5)	Pharmacodynamic investigation on novel targeted formulation/drug in Rheumatoid arthritis	Bhabha Atomic Research centre (BARC), Chembur, Mumbai

Consultancy Services: (in last five years)

Sr no.	Title	Industry/institute
1)	Drug evaluation	Shreya Life Sciences, Mumbai
2)	Preclinical R& D	Yasham P2D, Mumbai
3)	Product evaluation	Marico Ltd., Mumbai
4)	Acute and sub chronic oral & dermal toxicity studies	Lamar Group of companies
5)	Acute Oral Toxicity studies	Ayurchem Pvt. Ltd
6)	Acute Oral Toxicity studies	Charak Pharma Pvt. Ltd.
7)	Confidential	Hindustan Unilever Ltd

Research Area and interest:

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Pharmacological screening and evaluation of molecules of herbal and synthetic origin in the areas of: * Inflammation and immunology * Cardiovascular, vascular endothelial dysfunction and respiratory diseases * Cancer * Diabetes and metabolic disorders * Neurodegeneration and other CNS disorders * Chronic kidney diseases * GVHD

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Evaluation of photosensitivity of drugs & formulations and strategies for improving photo stability and minimizing photo toxicity.

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Research on SIRT modulators in smokeless tobacco related exacerbation of cardiovascular and metabolic complications in estrogen deficient states.

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Research on role of receptors and targets in cigarette smoke induced neurogenic pain and inflammation in lungs.

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Evaluation of herbals and synthetic molecules for various pharmacological activities.

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Toxicological testing, viz., acute, sub-acute, chronic toxicity, Dermal toxicity, Neurotoxicity, Cardiotoxicity, Endocrine disruption, Neuronal toxicity, Vascular toxicity etc. using various animal models (Rat, Mice, Guinea pig & Rabbits).

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Preclinical pharmacokinetic studies.

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Behavioural pharmacology

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Zebra fish as a model for investigating developmental toxicity, reproductive toxicity & whole body apoptosis.

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Effect of heavy metals and environmental toxicants on CNS.

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Haematopoietic Stem Cell Transplantation and complications associated with it (Graft Versus Host Disease& Hepatic Veno Occlusive Disease).

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In- vitro screening of anti-cancer drug molecule for its cytotoxicity (MTT assay, SRB assay), live cell as well as fixed cell imaging for entrapment of anti-cancer drug molecule inside the cells.

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Pre-clinical murine model development for in- vivo pre-clinical evaluation of anti- cancer drug molecule.

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Intracerebroventricular drug delivery using stereotaxic apparatus and Cerebrospinal fluid (CSF) tapping/aspiration for biomarker and drug/metabolite analysis.

Expertise and instrumental/research facilities you can provide to interested parties:

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Radio-immuno assay lab authorised by Atomic Energy Regulatory Board (AERB) Mammalian cell culture lab along with proteomics and genomics-based research facilitiesRadio-immuno assay lab authorised by Atomic Energy Regulatory Board (AERB) as well.

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My lab has an established proteomics and genomics laboratory such as: a. Gel electrophoresis and gel documentation system. b. Thermal cycler and real time polymerase chain reaction, which helps unearth molecular pathways in diseases by gene and protein expression studies. c. Techniques like western blotting and immunohistochemistry are also performed in the laboratory

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It comprises of laboratories dedicated to non-rodent model systems such as zebrafish and Drosophila melanogaster which are useful in carrying out studies related to neurodegeneration, hepatotoxicity and diabetes.

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Zebra fish as a model for investigating developmental toxicity, reproductive toxicity & whole-body apoptosis.

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Pre-clinical murine model development for in- vivo pre-clinical evaluation of anti- cancer drug molecule.

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Intracerebroventricular drug delivery using stereotaxic apparatus and Cerebrospinal fluid (CSF) tapping/aspiration for biomarker and drug/metabolite analysis.

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Preclinical R & D.

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Rodent Lab for psycho/ behavioral pharmacological studies.

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We also provide consultancy services to several industries in pharmacology and toxicology.

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